PremPLI: a machine learning model for predicting the effects of missense mutations on protein-ligand interactions

Resistance to small-molecule drugs is the main cause of the failure of therapeutic drugs in clinical practice. Missense mutations altering the binding of ligands to proteins are one of the critical mechanisms that result in genetic disease and drug resistance. Computational methods have made a lot o...

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Detalles Bibliográficos
Autores principales: Sun, Tingting, Chen, Yuting, Wen, Yuhao, Zhu, Zefeng, Li, Minghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604987/
https://www.ncbi.nlm.nih.gov/pubmed/34799678
http://dx.doi.org/10.1038/s42003-021-02826-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604987/
https://www.ncbi.nlm.nih.gov/pubmed/34799678
http://dx.doi.org/10.1038/s42003-021-02826-3

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