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PremPLI: a machine learning model for predicting the effects of missense mutations on protein-ligand interactions
Resistance to small-molecule drugs is the main cause of the failure of therapeutic drugs in clinical practice. Missense mutations altering the binding of ligands to proteins are one of the critical mechanisms that result in genetic disease and drug resistance. Computational methods have made a lot o...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604987/ https://www.ncbi.nlm.nih.gov/pubmed/34799678 http://dx.doi.org/10.1038/s42003-021-02826-3 |