Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity

Plasmodium falciparum-infected erythrocytes (IE) sequester in the placenta via surface protein VAR2CSA, which binds chondroitin sulfate A (CSA) expressed on the syncytiotrophoblast surface, causing placental malaria (PM) and severe adverse outcomes in mothers and their offspring. VAR2CSA belongs to...

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Detalles Bibliográficos
Autores principales: Renn, Jonathan P., Doritchamou, Justin Y. A., Tentokam, Bergeline C. Nguemwo, Morrison, Robert D., Cowles, Matthew V., Burkhardt, Martin, Ma, Rui, Mahamar, Almahamoudou, Attaher, Oumar, Diarra, Bacary S., Traore, Moussa, Dicko, Alassane, Tolia, Niraj H., Fried, Michal, Duffy, Patrick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604988/
https://www.ncbi.nlm.nih.gov/pubmed/34799664
http://dx.doi.org/10.1038/s42003-021-02787-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604988/
https://www.ncbi.nlm.nih.gov/pubmed/34799664
http://dx.doi.org/10.1038/s42003-021-02787-7

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