Clathrin adapters AP-1 and GGA2 support expression of epidermal growth factor receptor for cell growth

The role of Golgi/endosome-localized clathrin adapters in the maintenance of steady-state cell surface epidermal growth factor receptor (EGFR) is not well known. Here, we show that EGFR associates preferentially with both AP-1 and GGA2 in vitro. AP-1 depletion caused a reduction in the EGFR protein...

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Detalles Bibliográficos
Autores principales: Uemura, Takefumi, Suzuki, Takehiro, Dohmae, Naoshi, Waguri, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604998/
https://www.ncbi.nlm.nih.gov/pubmed/34799560
http://dx.doi.org/10.1038/s41389-021-00367-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604998/
https://www.ncbi.nlm.nih.gov/pubmed/34799560
http://dx.doi.org/10.1038/s41389-021-00367-2

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