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Ion permeation controlled by hydrophobic residues and proton binding in the proton-activated chloride channel
Recently identified proton-activated chloride channel (PAC) contains two transmembrane helices (S1–S2) and is involved in lysosome function, hypoxia adaption, stroke, and carcinogenesis. Although a PAC structure was recently resolved, its gating and activation mechanisms remained largely unknown. By...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605177/ https://www.ncbi.nlm.nih.gov/pubmed/34825147 http://dx.doi.org/10.1016/j.isci.2021.103395 |