Cargando…
Ion permeation controlled by hydrophobic residues and proton binding in the proton-activated chloride channel
Recently identified proton-activated chloride channel (PAC) contains two transmembrane helices (S1–S2) and is involved in lysosome function, hypoxia adaption, stroke, and carcinogenesis. Although a PAC structure was recently resolved, its gating and activation mechanisms remained largely unknown. By...
Autores principales: | Cai, Ruiqi, Tang, Jingfeng, Chen, Xing-Zhen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605177/ https://www.ncbi.nlm.nih.gov/pubmed/34825147 http://dx.doi.org/10.1016/j.isci.2021.103395 |
Ejemplares similares
-
Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels
por: Zheng, Wang, et al.
Publicado: (2018) -
Author Correction: Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels
por: Zheng, Wang, et al.
Publicado: (2019) -
Hydrophobic Gating of Ion Permeation in Magnesium Channel CorA
por: Neale, Chris, et al.
Publicado: (2015) -
Mechanism of Ion Permeation in Skeletal Muscle Chloride Channels
por: Fahlke, Christoph, et al.
Publicado: (1997) -
Temperature dependence of proton permeation through a voltage-gated proton channel
por: Kuno, Miyuki, et al.
Publicado: (2009)