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Ion permeation controlled by hydrophobic residues and proton binding in the proton-activated chloride channel

Recently identified proton-activated chloride channel (PAC) contains two transmembrane helices (S1–S2) and is involved in lysosome function, hypoxia adaption, stroke, and carcinogenesis. Although a PAC structure was recently resolved, its gating and activation mechanisms remained largely unknown. By...

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Detalles Bibliográficos
Autores principales: Cai, Ruiqi, Tang, Jingfeng, Chen, Xing-Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605177/
https://www.ncbi.nlm.nih.gov/pubmed/34825147
http://dx.doi.org/10.1016/j.isci.2021.103395

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