Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice

Eukaryotic initiation factor 5A (eIF5A), is an essential protein that requires a unique amino acid, hypusine, for its activity. Hypusine is formed exclusively in eIF5A post-translationally via two enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase. Each of the genes encoding these...

Descripción completa

Detalles Bibliográficos
Autores principales: Kar, Rajesh Kumar, Hanner, Ashleigh S., Starost, Matthew F., Springer, Danielle, Mastracci, Teresa L., Mirmira, Raghavendra G., Park, Myung Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605248/
https://www.ncbi.nlm.nih.gov/pubmed/34688659
http://dx.doi.org/10.1016/j.jbc.2021.101333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605248/
https://www.ncbi.nlm.nih.gov/pubmed/34688659
http://dx.doi.org/10.1016/j.jbc.2021.101333

Ejemplares similares