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Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice

Eukaryotic initiation factor 5A (eIF5A), is an essential protein that requires a unique amino acid, hypusine, for its activity. Hypusine is formed exclusively in eIF5A post-translationally via two enzymes, deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase. Each of the genes encoding these...

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Detalles Bibliográficos
Autores principales:	Kar, Rajesh Kumar, Hanner, Ashleigh S., Starost, Matthew F., Springer, Danielle, Mastracci, Teresa L., Mirmira, Raghavendra G., Park, Myung Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605248/ https://www.ncbi.nlm.nih.gov/pubmed/34688659 http://dx.doi.org/10.1016/j.jbc.2021.101333

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