Chromosome length and gene density contribute to micronuclear membrane stability

Micronuclei are derived from missegregated chromosomes and frequently lose membrane integrity, leading to DNA damage, innate immune activation, and metastatic signaling. Here, we demonstrate that two characteristics of the trapped chromosome, length and gene density, are key contributors to micronuc...

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Detalles Bibliográficos
Autores principales: Mammel, Anna E, Huang, Heather Z, Gunn, Amanda L, Choo, Emma, Hatch, Emily M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605325/
https://www.ncbi.nlm.nih.gov/pubmed/34789512
http://dx.doi.org/10.26508/lsa.202101210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605325/
https://www.ncbi.nlm.nih.gov/pubmed/34789512
http://dx.doi.org/10.26508/lsa.202101210

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