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Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs
We herein developed a transformable mixing-type material for reversible PEGylation of protein drugs using a supramolecular backbone polymer, that is, polyrotaxane possessing both amino groups and PEG chains (PEG–NH(2)–PRX). We expected that PEG–NH(2)–PRX provides amino groups to interact with protei...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605344/ https://www.ncbi.nlm.nih.gov/pubmed/34841242 http://dx.doi.org/10.1016/j.mtbio.2021.100160 |
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author | Utatsu, Kosei Kogo, Tetsuya Taharabaru, Toru Onodera, Risako Motoyama, Keiichi Higashi, Taishi |
author_facet | Utatsu, Kosei Kogo, Tetsuya Taharabaru, Toru Onodera, Risako Motoyama, Keiichi Higashi, Taishi |
author_sort | Utatsu, Kosei |
collection | PubMed |
description | We herein developed a transformable mixing-type material for reversible PEGylation of protein drugs using a supramolecular backbone polymer, that is, polyrotaxane possessing both amino groups and PEG chains (PEG–NH(2)–PRX). We expected that PEG–NH(2)–PRX provides amino groups to interact with protein drugs on demand because the mobility of amino groups in PEG–NH(2)–PRX was high. In fact, PEG–NH(2)–PRX formed complexes with protein drugs efficiently compared to PEGylated amino-dextran (PEG–NH(2)–DEX), a control material fabricated with a macromolecular backbone polymer. Moreover, PEG–NH(2)–PRX markedly improved the stability of antibodies and prolonged the hypoglycemic effects of insulin without loss of bioactivity, compared to PEG–NH(2)–DEX. These findings suggest that the supramolecular material, PEG–NH(2)–PRX, is a promising reversible PEGylation material for protein drugs compared to macromolecular materials. |
format | Online Article Text |
id | pubmed-8605344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-86053442021-11-26 Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs Utatsu, Kosei Kogo, Tetsuya Taharabaru, Toru Onodera, Risako Motoyama, Keiichi Higashi, Taishi Mater Today Bio Full Length Article We herein developed a transformable mixing-type material for reversible PEGylation of protein drugs using a supramolecular backbone polymer, that is, polyrotaxane possessing both amino groups and PEG chains (PEG–NH(2)–PRX). We expected that PEG–NH(2)–PRX provides amino groups to interact with protein drugs on demand because the mobility of amino groups in PEG–NH(2)–PRX was high. In fact, PEG–NH(2)–PRX formed complexes with protein drugs efficiently compared to PEGylated amino-dextran (PEG–NH(2)–DEX), a control material fabricated with a macromolecular backbone polymer. Moreover, PEG–NH(2)–PRX markedly improved the stability of antibodies and prolonged the hypoglycemic effects of insulin without loss of bioactivity, compared to PEG–NH(2)–DEX. These findings suggest that the supramolecular material, PEG–NH(2)–PRX, is a promising reversible PEGylation material for protein drugs compared to macromolecular materials. Elsevier 2021-11-16 /pmc/articles/PMC8605344/ /pubmed/34841242 http://dx.doi.org/10.1016/j.mtbio.2021.100160 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Full Length Article Utatsu, Kosei Kogo, Tetsuya Taharabaru, Toru Onodera, Risako Motoyama, Keiichi Higashi, Taishi Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs |
title | Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs |
title_full | Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs |
title_fullStr | Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs |
title_full_unstemmed | Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs |
title_short | Supramolecular polymer-based transformable material for reversible PEGylation of protein drugs |
title_sort | supramolecular polymer-based transformable material for reversible pegylation of protein drugs |
topic | Full Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605344/ https://www.ncbi.nlm.nih.gov/pubmed/34841242 http://dx.doi.org/10.1016/j.mtbio.2021.100160 |
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