Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3

BACKGROUND: Diabetes mellitus (DM), a most common chronic disease, is featured with impaired endothelial function and bioavailability of nitric oxide (NO), while E3 ubiquitin ligase appears to alleviate endothelial dysfunction as a promising option for DM treatment. Herein, we aimed to determine whe...

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Detalles Bibliográficos
Autores principales: Jin, Qingsong, Lin, Liangyan, Zhao, Tiantian, Yao, Xiaoyan, Teng, Yaqin, Zhang, Dongdong, Jin, Yongjun, Yang, Meizi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605525/
https://www.ncbi.nlm.nih.gov/pubmed/34798872
http://dx.doi.org/10.1186/s12967-021-03069-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605525/
https://www.ncbi.nlm.nih.gov/pubmed/34798872
http://dx.doi.org/10.1186/s12967-021-03069-w

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