Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function

BACKGROUND: Wolfram syndrome (WFS) is a rare autosomal recessive syndrome in which diabetes mellitus and neurodegenerative disorders occur as a result of Wolframin deficiency and increased ER stress. In addition, WFS1 deficiency leads to calcium homeostasis disturbances and can change mitochondrial...

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Detalles Bibliográficos
Autores principales: Zmyslowska, Agnieszka, Kuljanin, Miljan, Malachowska, Beata, Stanczak, Marcin, Michalek, Dominika, Wlodarczyk, Aneta, Grot, Dagmara, Taha, Joanna, Pawlik, Bartłomiej, Lebiedzińska-Arciszewska, Magdalena, Nieznanska, Hanna, Wieckowski, Mariusz R., Rieske, Piotr, Mancias, Joseph D., Borowiec, Maciej, Mlynarski, Wojciech, Fendler, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605533/
https://www.ncbi.nlm.nih.gov/pubmed/34801048
http://dx.doi.org/10.1186/s12964-021-00791-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605533/
https://www.ncbi.nlm.nih.gov/pubmed/34801048
http://dx.doi.org/10.1186/s12964-021-00791-2

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