Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2H-Chromen-2-One Activates CREB-Mediated Neuroprotection in Aβ and Tau Cell Models of Alzheimer's Disease

Abnormal accumulations of misfolded Aβ and tau proteins are major components of the hallmark plaques and neurofibrillary tangles in the brains of Alzheimer's disease (AD) patients. These abnormal protein deposits cause neurodegeneration through a number of proposed mechanisms, including downreg...

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Detalles Bibliográficos
Autores principales: Chiu, Ya-Jen, Lin, Te-Hsien, Chen, Chiung-Mei, Lin, Chih-Hsin, Teng, Yu-Shan, Lin, Chung-Yin, Sun, Ying-Chieh, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan, Lee-Chen, Guey-Jen, Lin, Wenwei, Chang, Kuo-Hsuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605905/
https://www.ncbi.nlm.nih.gov/pubmed/34812274
http://dx.doi.org/10.1155/2021/3058861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605905/
https://www.ncbi.nlm.nih.gov/pubmed/34812274
http://dx.doi.org/10.1155/2021/3058861

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