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Potentiation of cognitive enhancer effects of Alzheimer’s disease medication memantine by alpha7 nicotinic acetylcholine receptor agonist PHA-543613 in the Morris water maze task

RATIONALE: There are controversial pieces of evidence whether combination therapies using memantine and cholinesterase inhibitors are beneficial over their monotreatments. However, results of preclinical studies are promising when memantine is combined with agonists and allosteric modulators of the...

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Detalles Bibliográficos
Autores principales: Bruszt, Nóra, Bali, Zsolt Kristóf, Tadepalli, Sai Ambika, Nagy, Lili Veronika, Hernádi, István
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605977/
https://www.ncbi.nlm.nih.gov/pubmed/34387707
http://dx.doi.org/10.1007/s00213-021-05942-4