CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition

BACKGROUND: Diabetic nephropathy (DN) is a common complication of diabetes mellitus. Accumulating studies suggest that the deregulation of circular RNA (circRNA) is involved in DN pathogenesis. This study aimed to investigate the role of circSMAD4 in DN models. METHODS: Mice were treated with strept...

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Detalles Bibliográficos
Autores principales: Wu, Rina, Niu, Zheli, Ren, Guangwei, Ruan, Lin, Sun, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606083/
https://www.ncbi.nlm.nih.gov/pubmed/34801077
http://dx.doi.org/10.1186/s13098-021-00753-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606083/
https://www.ncbi.nlm.nih.gov/pubmed/34801077
http://dx.doi.org/10.1186/s13098-021-00753-1

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