Production of Long-Acting CNGRC–CPG2 Fusion Proteins: New Derivatives to Overcome Drug Immunogenicity of Ligand-Directed Enzyme Prodrug Therapy for Targeted Cancer Treatment

Objectives: Aminopeptidase N (APN) is an enzyme highly expressed in metastatic cancers and could be used in targeted cancer therapy. Our previous work showed the successful construction of CNGRC–carboxypeptidase G2 (CPG2) and CNGRC–CPG2–CNGRC fusion proteins. Our conjugates and prodrugs were effecti...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-mansoori, Layla, Al Qahtani, Alanod D., Elsinga, Philip, Goda, Sayed K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606725/
https://www.ncbi.nlm.nih.gov/pubmed/34802309
http://dx.doi.org/10.1177/15330338211057371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606725/
https://www.ncbi.nlm.nih.gov/pubmed/34802309
http://dx.doi.org/10.1177/15330338211057371

Ejemplares similares