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Cardiomyocyte protein O-GlcNAcylation is regulated by GFAT1 not GFAT2

In response to cardiac injury, increased activity of the hexosamine biosynthesis pathway (HBP) is linked with cytoprotective as well as adverse effects depending on the type and duration of injury. Glutamine-fructose amidotransferase (GFAT; gene name gfpt) is the rate-limiting enzyme that controls f...

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Detalles Bibliográficos
Autores principales: A Nabeebaccus, Adam, Verma, Sharwari, Zoccarato, Anna, Emanuelli, Giulia, Santos, Celio XC., Streckfuss-Bömeke, Katrin, Shah, Ajay M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606754/
https://www.ncbi.nlm.nih.gov/pubmed/34735873
http://dx.doi.org/10.1016/j.bbrc.2021.10.056