Phosphorylation of Lamin A/C at serine 22 modulates Na(v)1.5 function

Variants in the LMNA gene, which encodes for Lamin A/C, are associated with cardiac conduction disease (CCD). We previously reported that Lamin A/C variants p.R545H and p.A287Lfs*193, which were identified in CCD patients, decreased peak I (Na) in HEK‐293 cells expressing Na(v)1.5. Decreased peak I...

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Detalles Bibliográficos
Autores principales: Olaopa, Michael A., Ai, Tomohiko, Chao, Bo, Xiao, Xiangshu, Vatta, Matteo, Habecker, Beth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606869/
https://www.ncbi.nlm.nih.gov/pubmed/34806324
http://dx.doi.org/10.14814/phy2.15121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606869/
https://www.ncbi.nlm.nih.gov/pubmed/34806324
http://dx.doi.org/10.14814/phy2.15121

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