MiRNA-Mediated Knock-Down of Bcl-2 and Mcl-1 Increases Fludarabine-Sensitivity in CLL-CII Cells

BACKGROUND: Over-expression of anti-apoptotic proteins such as Bcl-2 and Mcl-1 is associated with resistance to chemotherapeutic agents such as fludarabine. Moreover, an inverse relationship between miRNA-15a levels with Bcl-2 and Mcl-1 expression has been observed in CLL patients. In this study, th...

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Detalles Bibliográficos
Autores principales: Ashofteh, Nooshin, Amini, Razieh, Molaee, Neda, Karami, Hadi, Baazm, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607086/
https://www.ncbi.nlm.nih.gov/pubmed/34319043
http://dx.doi.org/10.31557/APJCP.2021.22.7.2191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607086/
https://www.ncbi.nlm.nih.gov/pubmed/34319043
http://dx.doi.org/10.31557/APJCP.2021.22.7.2191

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