Cargando…

Hepatocyte-derived exosomal miR-27a activateshepatic stellate cells through the inhibitionof PINK1-mediated mitophagy in MAFLD

The role of exosome-mediated mitophagy in the crosstalk between hepatocytes (HCs) and hepatic stellate cells (HSCs) in metabolic-associated fatty liver disease (MAFLD) remains unknown. Serum exosomal miR-27a levels were markedly increased and positively correlated with liver fibrosis in MAFLD patien...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Xin, Xu, Zi-Xin, Wu, Jun-Cheng, Luo, Sheng-Zheng, Xu, Ming-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607138/ https://www.ncbi.nlm.nih.gov/pubmed/34853724 http://dx.doi.org/10.1016/j.omtn.2021.10.022

Ejemplares similares

Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease
por: Luo, Xin, et al.
Publicado: (2021)

Hepatocyte-derived exosomal miR-146a-5p inhibits hepatic stellate cell EMT process: a crosstalk between hepatocytes and hepatic stellate cells
por: Lang, Zhichao, et al.
Publicado: (2023)

MitoQ inhibits hepatic stellate cell activation and liver fibrosis by enhancing PINK1/parkin-mediated mitophagy
por: Dou, Shi-Ying, et al.
Publicado: (2021)

Role of Pink1-mediated mitophagy in adenomyosis
por: Chen, Minmin, et al.
Publicado: (2023)

ZNF281 drives hepatocyte senescence in alcoholic liver disease by reducing HK2‐stabilized PINK1/Parkin‐mediated mitophagy
por: Lu, Chunfeng, et al.
Publicado: (2022)

Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin–Mediated Mitophagy
por: Zhang, Yu, et al.
Publicado: (2023)

Zinc oxide nanoparticles induce toxicity in CAL 27 oral cancer cell lines by activating PINK1/Parkin-mediated mitophagy
por: Wang, Jianfeng, et al.
Publicado: (2018)

Drp1 regulated PINK1-dependent mitophagy protected duck follicular granulosa cells from acute heat stress injury
por: Yang, Chen, et al.
Publicado: (2023)

Mitophagy and Parkinson's disease: The PINK1–parkin link()
por: Deas, Emma, et al.
Publicado: (2011)

Inhibition of miR-421 Preserves Mitochondrial Function and Protects against Parkinson's Disease Pathogenesis via Pink1/Parkin-Dependent Mitophagy
por: Dong, Xiaolin, et al.
Publicado: (2022)

Erythropoietin Mitigates Diabetic Nephropathy by Restoring PINK1/Parkin-Mediated Mitophagy
por: Yi, Xinyao, et al.
Publicado: (2022)

MiR-27a as a predictor for the activation of hepatic stellate cells and hepatitis B virus-induced liver cirrhosis
por: Zhang, Hui, et al.
Publicado: (2017)

Pink1/PARK2/mROS-Dependent Mitophagy Initiates the Sensitization of Cancer Cells to Radiation
por: Yu, Lei, et al.
Publicado: (2021)

PINK1-induced mitophagy promotes neuroprotection in Huntington's disease
por: Khalil, B, et al.
Publicado: (2015)

Loss of iron triggers PINK1/Parkin-independent mitophagy
por: Allen, George F G, et al.
Publicado: (2013)

PINK1 mediates spinal cord mitophagy in neuropathic pain
por: Yi, Min-Hee, et al.
Publicado: (2019)

PINK1‐mediated mitophagy maintains pluripotency through optineurin
por: Wang, Chaoqun, et al.
Publicado: (2021)

PINK1: From Parkinson’s disease to mitophagy and back again
por: O’Callaghan, Benjamin, et al.
Publicado: (2023)

Exosomal transfer of obesity adipose tissue for decreased miR-141-3p mediate insulin resistance of hepatocytes
por: Dang, Shi-Ying, et al.
Publicado: (2019)

PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury
por: Wu, Weiwei, et al.
Publicado: (2015)

miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)
por: Kim, Jaekwang, et al.
Publicado: (2016)

OGG1 aggravates renal ischemia–reperfusion injury by repressing PINK1‐mediated mitophagy
por: Zhao, Fan, et al.
Publicado: (2023)

The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation
por: Panera, Nadia, et al.
Publicado: (2021)

miR-182-5p promotes hepatocyte-stellate cell crosstalk to facilitate liver regeneration
por: Xiao, Ting, et al.
Publicado: (2022)

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications
por: Durcan, Thomas M., et al.
Publicado: (2015)

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
por: Lazarou, Michael, et al.
Publicado: (2015)

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila
por: Cornelissen, Tom, et al.
Publicado: (2018)

PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses
por: Tsubouchi, Kazuya, et al.
Publicado: (2018)

PINK1 mediates spinal cord mitophagy in neuropathic pain [Corrigendum]
Publicado: (2019)

Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis
por: Shin, Hyo Jung, et al.
Publicado: (2019)

PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
por: Li, Jie, et al.
Publicado: (2022)

Inhibition of mitoNEET induces Pink1-Parkin-mediated mitophagy
por: Lee, Seunghee, et al.
Publicado: (2022)

Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells
por: Lee, Young-Sun, et al.
Publicado: (2017)

A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit
por: Waters, Christopher S., et al.
Publicado: (2023)

Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans
por: Yang, Xin, et al.
Publicado: (2020)

Berberine alleviates cisplatin-induced acute kidney injury by regulating mitophagy via PINK 1/Parkin pathway
por: Qi, Jieying, et al.
Publicado: (2020)

Samm50 Promotes Hypertrophy by Regulating Pink1-Dependent Mitophagy Signaling in Neonatal Cardiomyocytes
por: Xu, Ran, et al.
Publicado: (2021)

Type 2 diabetes‐induced hyposalivation of the submandibular gland through PINK1/Parkin‐mediated mitophagy
por: Xiang, Ruo‐Lan, et al.
Publicado: (2019)

Pink Disease. A Review of 27 Cases
por: Griffith, Gwyn
Publicado: (1950)

Exosomes Regulate Interclonal Communication on Osteogenic Differentiation Among Heterogeneous Osteogenic Single-Cell Clones Through PINK1/Parkin-Mediated Mitophagy
por: Fei, Dongdong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9hbkd4ut050dh746uo2kp4f589