Lineage-tracing and translatomic analysis of damage-inducible mitotic cochlear progenitors identifies candidate genes regulating regeneration

Cochlear supporting cells (SCs) are glia-like cells critical for hearing function. In the neonatal cochlea, the greater epithelial ridge (GER) is a mitotically quiescent and transient organ, which has been shown to nonmitotically regenerate SCs. Here, we ablated Lgr5(+) SCs using Lgr5-DTR mice and f...

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Detalles Bibliográficos
Autores principales: Udagawa, Tomokatsu, Atkinson, Patrick J., Milon, Beatrice, Abitbol, Julia M., Song, Yang, Sperber, Michal, Huarcaya Najarro, Elvis, Scheibinger, Mirko, Elkon, Ran, Hertzano, Ronna, Cheng, Alan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608324/
https://www.ncbi.nlm.nih.gov/pubmed/34758021
http://dx.doi.org/10.1371/journal.pbio.3001445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608324/
https://www.ncbi.nlm.nih.gov/pubmed/34758021
http://dx.doi.org/10.1371/journal.pbio.3001445

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