Cargando…

Integrating genome-wide association and transcriptome prediction model identifies novel target genes for osteoporosis

SUMMARY: In this study, we integrated large-scale GWAS summary data and used the predicted transcriptome-wide association study method to discover novel genes associated with osteoporosis. We identified 204 candidate genes, which provide novel clues for understanding the genetic mechanism of osteopo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, M., Yin, P., Hu, F., Jiang, J., Yin, L., Li, Y., Wang, S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer London 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608767/ https://www.ncbi.nlm.nih.gov/pubmed/34142171 http://dx.doi.org/10.1007/s00198-021-06024-z

Ejemplares similares

Integrating genome-wide association study with regulatory SNP annotations identified novel candidate genes for osteoporosis
por: Jia, Yumeng, et al.
Publicado: (2023)

Genome-Wide Association and Transcriptome-Wide Association Studies Identify Novel Susceptibility Genes Contributing to Colorectal Cancer
por: Yin, Ruimin, et al.
Publicado: (2022)

Integrative Analysis of Genomics and Transcriptome Data to Identify Regulation Networks in Female Osteoporosis
por: Zhang, Xianzuo, et al.
Publicado: (2020)

Integrated analysis of proteome-wide and transcriptome-wide association studies identified novel genes and chemicals for vertigo
por: Cheng, Bolun, et al.
Publicado: (2022)

Genome-Wide Association Study Identifies ALDH7A1 as a Novel Susceptibility Gene for Osteoporosis
por: Guo, Yan, et al.
Publicado: (2010)

Transcriptome-wide association study identifies novel candidate susceptibility genes for migraine
por: Meyers, Travis J., et al.
Publicado: (2023)

Genome-wide analysis of Chinese keloid patients identifies novel causative genes
por: Zhu, Yue-Qian, et al.
Publicado: (2022)

Identifying Novel Drug Targets for Epilepsy Through a Brain Transcriptome-Wide Association Study and Protein-Wide Association Study with Chemical-Gene-Interaction Analysis
por: Lu, Mengnan, et al.
Publicado: (2023)

Genome-wide approaches for identifying genetic risk factors for osteoporosis
por: Wu, Shuyan, et al.
Publicado: (2013)

Computational Characterization of Osteoporosis Associated SNPs and Genes Identified by Genome-Wide Association Studies
por: Qin, Longjuan, et al.
Publicado: (2016)

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
por: Ferreira, Manuel A., et al.
Publicado: (2019)

Genome- and Transcriptome-Wide Association Studies Identify Susceptibility Genes and Pathways for Periodontitis
por: Zhu, Guirong, et al.
Publicado: (2022)

An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits
por: Hsu, Yi-Hsiang, et al.
Publicado: (2010)

The Integration of Genome-Wide DNA Methylation and Transcriptomics Identifies the Potential Genes That Regulate the Development of Skeletal Muscles in Ducks
por: Lu, Yinglin, et al.
Publicado: (2023)

Integrating Genome-Wide Association Analysis With Transcriptome Sequencing to Identify Candidate Genes Related to Blooming Time in Prunus mume
por: Zhang, Man, et al.
Publicado: (2021)

Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis
por: Lu, Mengnan, et al.
Publicado: (2022)

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease
por: Sandholm, Niina, et al.
Publicado: (2022)

An Integrative Transcriptomic Analysis for Identifying Novel Target Genes Corresponding to Severity Spectrum in Spinal Muscular Atrophy
por: Yang, Chung-Wei, et al.
Publicado: (2016)

Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies
por: Khunsriraksakul, Chachrit, et al.
Publicado: (2022)

New novel non-MHC genes were identified for cervical cancer with an integrative analysis approach of transcriptome-wide association study
por: Chen, Haimiao, et al.
Publicado: (2021)

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head
por: Ma, Mei, et al.
Publicado: (2021)

Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis
por: Filkor, Kata, et al.
Publicado: (2013)

Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes
por: Li, Ling, et al.
Publicado: (2022)

GeneHancer: genome-wide integration of enhancers and target genes in GeneCards
por: Fishilevich, Simon, et al.
Publicado: (2017)

A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes
por: Sun, Yanfa, et al.
Publicado: (2021)

Integrative analysis of transcriptome-wide association study and gene expression profiling identifies candidate genes associated with stroke
por: Yang, Jian, et al.
Publicado: (2019)

Genome-wide investigation of gene-cancer associations for the prediction of novel therapeutic targets in oncology
por: Bazaga, Adrián, et al.
Publicado: (2020)

Probabilistic integration of transcriptome-wide association studies and colocalization analysis identifies key molecular pathways of complex traits
por: Okamoto, Jeffrey, et al.
Publicado: (2023)

Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders
por: Yao, Xueming, et al.
Publicado: (2021)

Benchmarking and integrating genome-wide CRISPR off-target detection and prediction
por: Yan, Jifang, et al.
Publicado: (2020)

Systematic druggable genome-wide Mendelian randomisation identifies therapeutic targets for Alzheimer’s disease
por: Su, Wei-Ming, et al.
Publicado: (2023)

Integration of genomics and transcriptomics predicts diabetic retinopathy susceptibility genes
por: Skol, Andrew D, et al.
Publicado: (2020)

Identifying celiac disease-related chemicals by transcriptome-wide association study and chemical-gene interaction analyses
por: Lu, Mengnan, et al.
Publicado: (2022)

Integration of transcriptome-wide association study and messenger RNA expression profile to identify genes associated with osteoarthritis
por: Qi, Xin, et al.
Publicado: (2020)

Integrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers
por: He, Jingni, et al.
Publicado: (2022)

Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder
por: Huang, Kunling, et al.
Publicado: (2021)

Comparative transcriptome analysis identifies CARM1 and DNMT3A as genes associated with osteoporosis
por: Panach, Layla, et al.
Publicado: (2020)

Integrated analysis of genome-wide DNA methylation and gene expression profiles identifies potential novel biomarkers of rectal cancer
por: Wei, Jiufeng, et al.
Publicado: (2016)

Identifying causal genes for migraine by integrating the proteome and transcriptome
por: Li, Shuang-jie, et al.
Publicado: (2023)

Genome-Wide Association Analyses Identify SPOCK as a Key Novel Gene Underlying Age at Menarche
por: Liu, Yao-Zhong, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_sr7876ou027os9eqbn8kn5scod