Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However, the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in targeting the pathway therapeutically. This mode of cell death is executed by the terminal effector, the MLKL pse...

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Detalles Bibliográficos
Autores principales: Meng, Yanxiang, Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Horne, Christopher R., Luo, Cindy, Garnier, Jean-Marc, Liang, Lung-Yu, Cowan, Angus D., Samson, Andre L., Lessene, Guillaume, Sandow, Jarrod J., Czabotar, Peter E., Murphy, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608796/
https://www.ncbi.nlm.nih.gov/pubmed/34811356
http://dx.doi.org/10.1038/s41467-021-27032-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608796/
https://www.ncbi.nlm.nih.gov/pubmed/34811356
http://dx.doi.org/10.1038/s41467-021-27032-x

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