A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems

Lipid nanoparticle (LNP)-formulated mRNA vaccines were rapidly developed and deployed in response to the SARS-CoV-2 pandemic. Due to the labile nature of mRNA, identifying impurities that could affect product stability and efficacy is crucial to the long-term use of nucleic-acid based medicines. Her...

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Detalles Bibliográficos
Autores principales: Packer, Meredith, Gyawali, Dipendra, Yerabolu, Ravikiran, Schariter, Joseph, White, Phil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608879/
https://www.ncbi.nlm.nih.gov/pubmed/34811367
http://dx.doi.org/10.1038/s41467-021-26926-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608879/
https://www.ncbi.nlm.nih.gov/pubmed/34811367
http://dx.doi.org/10.1038/s41467-021-26926-0

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