Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates

The main (Mpro) and papain-like (PLpro) proteases encoded by SARS-CoV-2 are essential to process viral polyproteins into functional units, thus representing key targets for anti-viral drug development. There is a need for an efficient inhibitor screening system that can identify drug candidates in a...

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Detalles Bibliográficos
Autores principales: Franko, Nik, Teixeira, Ana Palma, Xue, Shuai, Charpin-El Hamri, Ghislaine, Fussenegger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609006/
https://www.ncbi.nlm.nih.gov/pubmed/34811361
http://dx.doi.org/10.1038/s41467-021-27072-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609006/
https://www.ncbi.nlm.nih.gov/pubmed/34811361
http://dx.doi.org/10.1038/s41467-021-27072-3

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