Brain Acetyl-CoA Production and Phosphorylation of Cytoskeletal Proteins Are Targets of CYP46A1 Activity Modulation and Altered Sterol Flux

Cholesterol and 24-hydroxycholesterol are the most abundant brain sterols and represent the substrate and product, respectively, of cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme. CYP46A1 controls cholesterol elimination and turnover in the brain, the two processes that determine the rate of...

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Detalles Bibliográficos
Autores principales: Mast, Natalia, Petrov, Alexey M., Prendergast, Erin, Bederman, Ilya, Pikuleva, Irina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609074/
https://www.ncbi.nlm.nih.gov/pubmed/34235635
http://dx.doi.org/10.1007/s13311-021-01079-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609074/
https://www.ncbi.nlm.nih.gov/pubmed/34235635
http://dx.doi.org/10.1007/s13311-021-01079-6

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