Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation

Inflammatory bowel diseases (IBDs) are genetically complex and exhibit significant inter-patient heterogeneity in disease presentation and therapeutic response. Here, we show that mouse models of IBD exhibit variable responses to inhibition of MK2, a pro-inflammatory serine/threonine kinase, and tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Suarez-Lopez, Lucia, Shui, Bing, Brubaker, Douglas K., Hill, Marza, Bergendorf, Alexander, Changelian, Paul S., Laguna, Aisha, Starchenko, Alina, Lauffenburger, Douglas A., Haigis, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609096/
https://www.ncbi.nlm.nih.gov/pubmed/34849469
http://dx.doi.org/10.1016/j.isci.2021.103406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609096/
https://www.ncbi.nlm.nih.gov/pubmed/34849469
http://dx.doi.org/10.1016/j.isci.2021.103406

Ejemplares similares