Cargando…

piggyBac system to co-express NKG2D CAR and IL-15 to augment the in vivo persistence and anti-AML activity of human peripheral blood NK cells

Promising progress has been made in adoptive transfer of allogeneic natural killer (NK) cells to treat relapsed or refractory acute myeloid leukemia (AML). In this regard, chimeric antigen receptor (CAR)-modification of NK cells is considered as a compelling approach to augment the specificity and c...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Zhicheng, Ng, Yu Yang, Zha, Shijun, Wang, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609108/
https://www.ncbi.nlm.nih.gov/pubmed/34853803
http://dx.doi.org/10.1016/j.omtm.2021.10.014