Differential phase register of Hes1 oscillations with mitoses underlies cell-cycle heterogeneity in ER(+) breast cancer cells

Here, we study the dynamical expression of endogenously labeled Hes1, a transcriptional repressor implicated in controlling cell proliferation, to understand how cell-cycle length heterogeneity is generated in estrogen receptor (ER)(+) breast cancer cells. We find that Hes1 shows oscillatory express...

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Detalles Bibliográficos
Autores principales: Sabherwal, Nitin, Rowntree, Andrew, Marinopoulou, Elli, Pettini, Tom, Hourihane, Sean, Thomas, Riba, Soto, Ximena, Kursawe, Jochen, Papalopulu, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609326/
https://www.ncbi.nlm.nih.gov/pubmed/34725165
http://dx.doi.org/10.1073/pnas.2113527118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609326/
https://www.ncbi.nlm.nih.gov/pubmed/34725165
http://dx.doi.org/10.1073/pnas.2113527118

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