Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child

We describe an unvaccinated child at risk for life-threatening COVID-19 due to an inherited deficiency of IRF9, which governs ISGF-3–dependent responses to type I and III interferons (IFN). She was admitted, with a high nasal SARS-CoV-2 load on day 1 of upper respiratory tract infection. She was vir...

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Detalles Bibliográficos
Autores principales: Lévy, Romain, Zhang, Peng, Bastard, Paul, Dorgham, Karim, Melki, Isabelle, Hadchouel, Alice, Hartoularos, George C., Neven, Bénédicte, Castelle, Martin, Roy, Charlotte, Toin, Tom, Berteloot, Laureline, Bizien, Lucy, Abid, Hanène, Burgard, Marianne, Houhou-Fidouh, Nadhira, Rozenberg, Flore, Jouanguy, Emmanuelle, Ye, Chun Jimmie, Gorochov, Guy, Zhang, Qian, Casanova, Jean-Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609338/
https://www.ncbi.nlm.nih.gov/pubmed/34702736
http://dx.doi.org/10.1073/pnas.2114390118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609338/
https://www.ncbi.nlm.nih.gov/pubmed/34702736
http://dx.doi.org/10.1073/pnas.2114390118

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