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Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child
We describe an unvaccinated child at risk for life-threatening COVID-19 due to an inherited deficiency of IRF9, which governs ISGF-3–dependent responses to type I and III interferons (IFN). She was admitted, with a high nasal SARS-CoV-2 load on day 1 of upper respiratory tract infection. She was vir...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609338/ https://www.ncbi.nlm.nih.gov/pubmed/34702736 http://dx.doi.org/10.1073/pnas.2114390118 |
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| author | Lévy, Romain Zhang, Peng Bastard, Paul Dorgham, Karim Melki, Isabelle Hadchouel, Alice Hartoularos, George C. Neven, Bénédicte Castelle, Martin Roy, Charlotte Toin, Tom Berteloot, Laureline Bizien, Lucy Abid, Hanène Burgard, Marianne Houhou-Fidouh, Nadhira Rozenberg, Flore Jouanguy, Emmanuelle Ye, Chun Jimmie Gorochov, Guy Zhang, Qian Casanova, Jean-Laurent |
| author_facet | Lévy, Romain Zhang, Peng Bastard, Paul Dorgham, Karim Melki, Isabelle Hadchouel, Alice Hartoularos, George C. Neven, Bénédicte Castelle, Martin Roy, Charlotte Toin, Tom Berteloot, Laureline Bizien, Lucy Abid, Hanène Burgard, Marianne Houhou-Fidouh, Nadhira Rozenberg, Flore Jouanguy, Emmanuelle Ye, Chun Jimmie Gorochov, Guy Zhang, Qian Casanova, Jean-Laurent |
| author_sort | Lévy, Romain |
| collection | PubMed |
| description | We describe an unvaccinated child at risk for life-threatening COVID-19 due to an inherited deficiency of IRF9, which governs ISGF-3–dependent responses to type I and III interferons (IFN). She was admitted, with a high nasal SARS-CoV-2 load on day 1 of upper respiratory tract infection. She was viremic on day 2 and received casirivimab and imdevimab. Her clinical manifestations and viremia disappeared on days 3 and 4, respectively. Circulating SARS-CoV-2 virus induced the expression of IFN-stimulated genes in leukocytes on day 1, whereas the secretion of blood type I IFNs, which peaked on day 4, did not. Antibody-mediated SARS-CoV-2 neutralization is, therefore, sufficient to overcome a deficiency of antiviral IFNs. |
| format | Online Article Text |
| id | pubmed-8609338 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | National Academy of Sciences |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86093382021-12-02 Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child Lévy, Romain Zhang, Peng Bastard, Paul Dorgham, Karim Melki, Isabelle Hadchouel, Alice Hartoularos, George C. Neven, Bénédicte Castelle, Martin Roy, Charlotte Toin, Tom Berteloot, Laureline Bizien, Lucy Abid, Hanène Burgard, Marianne Houhou-Fidouh, Nadhira Rozenberg, Flore Jouanguy, Emmanuelle Ye, Chun Jimmie Gorochov, Guy Zhang, Qian Casanova, Jean-Laurent Proc Natl Acad Sci U S A Biological Sciences We describe an unvaccinated child at risk for life-threatening COVID-19 due to an inherited deficiency of IRF9, which governs ISGF-3–dependent responses to type I and III interferons (IFN). She was admitted, with a high nasal SARS-CoV-2 load on day 1 of upper respiratory tract infection. She was viremic on day 2 and received casirivimab and imdevimab. Her clinical manifestations and viremia disappeared on days 3 and 4, respectively. Circulating SARS-CoV-2 virus induced the expression of IFN-stimulated genes in leukocytes on day 1, whereas the secretion of blood type I IFNs, which peaked on day 4, did not. Antibody-mediated SARS-CoV-2 neutralization is, therefore, sufficient to overcome a deficiency of antiviral IFNs. National Academy of Sciences 2021-10-26 2021-11-09 /pmc/articles/PMC8609338/ /pubmed/34702736 http://dx.doi.org/10.1073/pnas.2114390118 Text en Copyright © 2021 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Biological Sciences Lévy, Romain Zhang, Peng Bastard, Paul Dorgham, Karim Melki, Isabelle Hadchouel, Alice Hartoularos, George C. Neven, Bénédicte Castelle, Martin Roy, Charlotte Toin, Tom Berteloot, Laureline Bizien, Lucy Abid, Hanène Burgard, Marianne Houhou-Fidouh, Nadhira Rozenberg, Flore Jouanguy, Emmanuelle Ye, Chun Jimmie Gorochov, Guy Zhang, Qian Casanova, Jean-Laurent Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child |
| title | Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child |
| title_full | Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child |
| title_fullStr | Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child |
| title_full_unstemmed | Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child |
| title_short | Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child |
| title_sort | monoclonal antibody-mediated neutralization of sars-cov-2 in an irf9-deficient child |
| topic | Biological Sciences |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609338/ https://www.ncbi.nlm.nih.gov/pubmed/34702736 http://dx.doi.org/10.1073/pnas.2114390118 |
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