Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation

Phosphoinositide 3-kinases (PI3Ks) are lipid kinases essential for growth and metabolism. Their aberrant activation is associated with many types of cancers. Here we used single-particle cryoelectron microscopy (cryo-EM) to determine three distinct conformations of full-length PI3Kα (p110α–p85α): th...

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Detalles Bibliográficos
Autores principales: Liu, Xiao, Yang, Su, Hart, Jonathan R., Xu, Yingna, Zou, Xinyu, Zhang, Huibing, Zhou, Qingtong, Xia, Tian, Zhang, Yan, Yang, Dehua, Wang, Ming-Wei, Vogt, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609346/
https://www.ncbi.nlm.nih.gov/pubmed/34725156
http://dx.doi.org/10.1073/pnas.2109327118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609346/
https://www.ncbi.nlm.nih.gov/pubmed/34725156
http://dx.doi.org/10.1073/pnas.2109327118

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