Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs

Calcineurin is a critical enzyme in fungal pathogenesis and antifungal drug tolerance and, therefore, an attractive antifungal target. Current clinically accessible calcineurin inhibitors, such as FK506, are immunosuppressive to humans, so exploiting calcineurin inhibition as an antifungal strategy...

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Detalles Bibliográficos
Autores principales: Gobeil, Sophie M.-C., Bobay, Benjamin G., Juvvadi, Praveen R., Cole, D. Christopher, Heitman, Joseph, Steinbach, William J., Venters, Ronald A., Spicer, Leonard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609367/
https://www.ncbi.nlm.nih.gov/pubmed/34809463
http://dx.doi.org/10.1128/mBio.03000-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609367/
https://www.ncbi.nlm.nih.gov/pubmed/34809463
http://dx.doi.org/10.1128/mBio.03000-21

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