Glutathione peroxidase 4 regulated neutrophil ferroptosis induces systemic autoimmunity

The linkage between neutrophil death and the development of autoimmunity has not been thoroughly explored. Here, we show that neutrophils from either lupus-prone mice or patients with systemic lupus erythematosus (SLE) undergo ferroptosis. Mechanistically, autoantibodies and interferon-α present in...

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Detalles Bibliográficos
Autores principales: Li, Pengchong, Jiang, Mengdi, Li, Ketian, Li, Hao, Zhou, Yangzhong, Xiao, Xinyue, Xu, Yue, Krishfield, Suzanne, Lipsky, Peter E, Tsokos, George C, Zhang, Xuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609402/
https://www.ncbi.nlm.nih.gov/pubmed/34385713
http://dx.doi.org/10.1038/s41590-021-00993-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609402/
https://www.ncbi.nlm.nih.gov/pubmed/34385713
http://dx.doi.org/10.1038/s41590-021-00993-3

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