HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio

BACKGROUND: During HIV-1 maturation, Gag and Gag-Pol polyproteins are proteolytically cleaved and the capsid protein polymerizes to form the honeycomb capsid lattice. HIV-1 integrase (IN) binds the viral genomic RNA (gRNA) and impairment of IN-gRNA binding leads to mis-localization of the nucleocaps...

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Detalles Bibliográficos
Autores principales: Liu, Shuohui, Koneru, Pratibha C., Li, Wen, Pathirage, Chathuri, Engelman, Alan N., Kvaratskhelia, Mamuka, Musier-Forsyth, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609798/
https://www.ncbi.nlm.nih.gov/pubmed/34809662
http://dx.doi.org/10.1186/s12977-021-00582-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609798/
https://www.ncbi.nlm.nih.gov/pubmed/34809662
http://dx.doi.org/10.1186/s12977-021-00582-0

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