Cargando…

HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio

BACKGROUND: During HIV-1 maturation, Gag and Gag-Pol polyproteins are proteolytically cleaved and the capsid protein polymerizes to form the honeycomb capsid lattice. HIV-1 integrase (IN) binds the viral genomic RNA (gRNA) and impairment of IN-gRNA binding leads to mis-localization of the nucleocaps...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Shuohui, Koneru, Pratibha C., Li, Wen, Pathirage, Chathuri, Engelman, Alan N., Kvaratskhelia, Mamuka, Musier-Forsyth, Karin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609798/ https://www.ncbi.nlm.nih.gov/pubmed/34809662 http://dx.doi.org/10.1186/s12977-021-00582-0

Ejemplares similares

Multimodal Functionalities of HIV-1 Integrase
por: Engelman, Alan N., et al.
Publicado: (2022)

Phosphomimetic S207D Lysyl–tRNA Synthetase Binds HIV-1 5′UTR in an Open Conformation and Increases RNA Dynamics
por: Cantara, William A., et al.
Publicado: (2022)

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis
por: Elliott, Jennifer L, et al.
Publicado: (2020)

A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site
por: Maehigashi, Tatsuya, et al.
Publicado: (2021)

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
por: Koneru, Pratibha C, et al.
Publicado: (2019)

Identification and Optimization of a Novel HIV-1 Integrase Inhibitor
por: Adu-Ampratwum, Daniel, et al.
Publicado: (2022)

HIV-1 Integrase-DNA Recognition Mechanisms
por: Kessl, Jacques J., et al.
Publicado: (2009)

The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function
por: Singer, Matthew R., et al.
Publicado: (2023)

Intrinsic conformational dynamics of the HIV-1 genomic RNA 5′UTR
por: Brigham, Benjamin S., et al.
Publicado: (2019)

The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication
por: Engelman, Alan, et al.
Publicado: (2008)

The mechanism of H171T resistance reveals the importance of N(δ)-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase
por: Slaughter, Alison, et al.
Publicado: (2014)

Virio- and Bacterioplankton Microscale Distributions at the Sediment-Water Interface
por: Dann, Lisa M., et al.
Publicado: (2014)

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor
por: Wang, Hao, et al.
Publicado: (2012)

Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins
por: Kudryashova, Elena, et al.
Publicado: (2016)

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence
por: Zhao, Xue Zhi, et al.
Publicado: (2018)

Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA
por: Shema Mugisha, Christian, et al.
Publicado: (2022)

A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase
por: Sharma, Amit, et al.
Publicado: (2014)

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75
por: Kessl, Jacques J., et al.
Publicado: (2011)

Molecular mechanisms of retroviral integration site selection
por: Kvaratskhelia, Mamuka, et al.
Publicado: (2014)

Engineered Hyperactive Integrase for Concerted HIV-1 DNA Integration
por: Li, Min, et al.
Publicado: (2014)

The Pleiotropic Effects of YBX1 on HTLV-1 Transcription
por: Smith, Susan, et al.
Publicado: (2023)

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding
por: Serrao, Erik, et al.
Publicado: (2014)

HIV-1 integrase SUMOylation and viral replication
por: Zamborlini, Alessia, et al.
Publicado: (2011)

Viral Respiratory Tract Infections in the Neonatal Intensive Care Unit: The VIRIoN-I Study
por: Ronchi, Andrea, et al.
Publicado: (2014)

Retroviral integrase protein and intasome nucleoprotein complex structures
por: Grawenhoff, Julia, et al.
Publicado: (2017)

Anticodon-like binding of the HIV-1 tRNA-like element to human lysyl-tRNA synthetase
por: Liu, Sheng, et al.
Publicado: (2016)

HIV-1 Gag Binds the Multi-Aminoacyl-tRNA Synthetase Complex via the EPRS Subunit
por: Jin, Danni, et al.
Publicado: (2023)

In virio SHAPE analysis of tRNA(Lys3) annealing to HIV-1 genomic RNA in wild type and protease-deficient virus
por: Seif, Elias, et al.
Publicado: (2015)

Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes
por: Larue, Ross C., et al.
Publicado: (2014)

Unfolding of DNA quadruplexes induced by HIV-1 nucleocapsid protein
por: Kankia, Besik I., et al.
Publicado: (2005)

Biochemical Characterization of Novel Retroviral Integrase Proteins
por: Ballandras-Colas, Allison, et al.
Publicado: (2013)

Functional Equivalence of Retroviral MA Domains in Facilitating Psi RNA Binding Specificity by Gag
por: Rye-McCurdy, Tiffiny, et al.
Publicado: (2016)

Distinct binding interactions of HIV-1 Gag to Psi and non-Psi RNAs: Implications for viral genomic RNA packaging
por: Webb, Joseph A., et al.
Publicado: (2013)

Conservation of tRNA mimicry in the 5′-untranslated region of distinct HIV-1 subtypes
por: Comandur, Roopa, et al.
Publicado: (2017)

Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase
por: Dar, Mohd J, et al.
Publicado: (2009)

Structural Basis for Functional Tetramerization of Lentiviral Integrase
por: Hare, Stephen, et al.
Publicado: (2009)

New Structure Sheds Light on Selective HIV-1 Genomic RNA Packaging
por: Olson, Erik D., et al.
Publicado: (2015)

Distributions and relationships of virio- and picoplankton in the epi-, meso- and bathypelagic zones of the Amundsen Sea, West Antarctica during the austral summer
por: Han, Meiaoxue, et al.
Publicado: (2022)

Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction
por: Aiyer, Sriram, et al.
Publicado: (2014)

Integrase and integration: biochemical activities of HIV-1 integrase
por: Delelis, Olivier, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_tvp52lsjotj25cpvn2iogsl8ov