Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro

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In addition to its essential role in viral polyprotein processing, the SARS-CoV-2 3C-like (3CLpro) protease can cleave human immune signaling proteins, like NF-κB Essential Modulator (NEMO) and deregulate the host immune response. Here, in vitro assays show that SARS-CoV-2 3CLpro cleaves NEMO with f...

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Detalles Bibliográficos
Autores principales: Hameedi, Mikhail Ali, Prates, Erica T., Garvin, Michael R., Mathews, Irimpan, Amos, B Kirtley, Demerdash, Omar, Bechthold, Mark, Iyer, Mamta, Rahighi, Simin, Kneller, Daniel W., Kovalevsky, Andrey, Irle, Stephan, Vuong, Van-Quan, Mitchell, Julie C., Labbe, Audrey, Galanie, Stephanie, Wakatsuki, Soichi, Jacobson, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609902/
https://www.ncbi.nlm.nih.gov/pubmed/34816264
http://dx.doi.org/10.1101/2021.11.11.468228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609902/
https://www.ncbi.nlm.nih.gov/pubmed/34816264
http://dx.doi.org/10.1101/2021.11.11.468228

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