Epitope spreading driven by the joint action of CART cells and pharmacological STING stimulation counteracts tumor escape via antigen-loss variants

BACKGROUND: Target antigen (Ag) loss has emerged as a major cause of relapse after chimeric antigen receptor T (CART)-cell therapy. We reasoned that the combination of CART cells, with the consequent tumor debulking and release of Ags, together with an immunomodulatory agent, such as the stimulator...

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Detalles Bibliográficos
Autores principales: Conde, Enrique, Vercher, Enric, Soria-Castellano, Marta, Suarez-Olmos, Jesús, Mancheño, Uxua, Elizalde, Edurne, Rodriguez, M Luis, Glez-Vaz, Javier, Casares, Noelia, Rodríguez-García, Estefanía, Hommel, Mirja, González-Aseguinolaza, Gloria, Uranga-Murillo, Iratxe, Pardo, Julian, Alkorta, Gorka, Melero, Ignacio, Lasarte, Juan, Hervas-Stubbs, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609946/
https://www.ncbi.nlm.nih.gov/pubmed/34810235
http://dx.doi.org/10.1136/jitc-2021-003351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8609946/
https://www.ncbi.nlm.nih.gov/pubmed/34810235
http://dx.doi.org/10.1136/jitc-2021-003351

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