Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition

Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number and size depends on balanced fusion and fission rates. Thus, conditions that favour fusion over fission can...

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Detalles Bibliográficos
Autores principales: Saffi, Golam T., Tang, Evan, Mamand, Sami, Inpanathan, Subothan, Fountain, Aaron, Salmena, Leonardo, Botelho, Roberto J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610251/
https://www.ncbi.nlm.nih.gov/pubmed/34813622
http://dx.doi.org/10.1371/journal.pone.0259313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610251/
https://www.ncbi.nlm.nih.gov/pubmed/34813622
http://dx.doi.org/10.1371/journal.pone.0259313

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