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Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition

Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number and size depends on balanced fusion and fission rates. Thus, conditions that favour fusion over fission can...

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Detalles Bibliográficos
Autores principales:	Saffi, Golam T., Tang, Evan, Mamand, Sami, Inpanathan, Subothan, Fountain, Aaron, Salmena, Leonardo, Botelho, Roberto J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610251/ https://www.ncbi.nlm.nih.gov/pubmed/34813622 http://dx.doi.org/10.1371/journal.pone.0259313

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