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The core Cas1 protein of CRISPR-Cas I-B in Leptospira shows metal-tunable nuclease activity

Leptospira interrogans serovar Copenhageni strain Fiocruz L1-130 is the causative agent of leptospirosis in animals and humans. This organism carries a functional cas1 gene classified under CRISPR-Cas I-B. In this study, using various nuclease assays and bioinformatics analysis, we report that the r...

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Detalles Bibliográficos
Autores principales: Dixit, Bhuvan, Prakash, Aman, Kumar, Pankaj, Gogoi, Prerana, Kumar, Manish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610301/
https://www.ncbi.nlm.nih.gov/pubmed/34841349
http://dx.doi.org/10.1016/j.crmicr.2021.100059