The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast, lack this class of enzymes. It remains an unanswered evolutionary question as to h...

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Detalles Bibliográficos
Autores principales: Bonilla, Braulio, Brown, Alexander J, Hengel, Sarah R, Rapchak, Kyle S, Mitchell, Debra, Pressimone, Catherine A, Fagunloye, Adeola A, Luong, Thong T, Russell, Reagan A, Vyas, Rudri K, Mertz, Tony M, Zaher, Hani S, Mosammaparast, Nima, Malc, Ewa P, Mieczkowski, Piotr A, Roberts, Steven A, Bernstein, Kara A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610418/
https://www.ncbi.nlm.nih.gov/pubmed/34723799
http://dx.doi.org/10.7554/eLife.68080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610418/
https://www.ncbi.nlm.nih.gov/pubmed/34723799
http://dx.doi.org/10.7554/eLife.68080

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