Inhibition of Autophagy Suppresses SARS-CoV-2 Replication and Ameliorates Pneumonia in hACE2 Transgenic Mice and Xenografted Human Lung Tissues

Autophagy is thought to be involved in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, how SARS-CoV-2 interferes with the autophagic pathway and whether autophagy contributes to virus infection in vivo is unclear. In this study, we identified SARS-CoV-2-triggered aut...

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Detalles Bibliográficos
Autores principales: Shang, Chao, Zhuang, Xinyu, Zhang, He, Li, Yiquan, Zhu, Yilong, Lu, Jing, Ge, Chenchen, Cong, Jianan, Li, Tingyu, Li, Nan, Tian, Mingyao, Jin, Ningyi, Li, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610582/
https://www.ncbi.nlm.nih.gov/pubmed/34550769
http://dx.doi.org/10.1128/JVI.01537-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610582/
https://www.ncbi.nlm.nih.gov/pubmed/34550769
http://dx.doi.org/10.1128/JVI.01537-21

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