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Convergent HIV-1 Evolution upon Targeted Destabilization of the gp120-gp41 Interface

The HIV-1 envelope glycoprotein (Env) trimer is responsible for viral entry into target cells and is the sole target of neutralizing antibodies. The Env protein is therefore the focus of HIV-1 vaccine design. Env consists of two noncovalently linked subunits (gp120 and gp41) that form a trimer of he...

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Detalles Bibliográficos
Autores principales:	Torrents de la Peña, Alba, del Moral Sánchez, Iván, Burger, Judith A., Bontjer, Ilja, Isik, Gözde, Eggink, Dirk, van Gils, Marit J., Sanders, Rogier W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610599/ https://www.ncbi.nlm.nih.gov/pubmed/34586861 http://dx.doi.org/10.1128/JVI.00532-21

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