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CSF Synaptic Biomarkers in the Preclinical Stage of Alzheimer Disease and Their Association With MRI and PET: A Cross-sectional Study

BACKGROUND AND OBJECTIVES: To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of the Alzheimer continuum and associated with Alzheimer disease (AD) risk factors, primary pathology, and neurodegeneration markers. METHODS: This cross-sectional study was performed i...

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Detalles Bibliográficos
Autores principales: Milà-Alomà, Marta, Brinkmalm, Ann, Ashton, Nicholas J., Kvartsberg, Hlin, Shekari, Mahnaz, Operto, Grégory, Salvadó, Gemma, Falcon, Carles, Gispert, Juan Domingo, Vilor-Tejedor, Natalia, Arenaza-Urquijo, Eider M., Grau-Rivera, Oriol, Sala-Vila, Aleix, Sanchez-Benavides, Gonzalo, González-de-Echávarri, José María, Minguillon, Carolina, Fauria, Karine, Niñerola-Baizán, Aida, Perissinotti, Andrés, Kollmorgen, Gwendlyn, Suridjan, Ivonne, Zetterberg, Henrik, Molinuevo, José Luis, Blennow, Kaj, Suárez-Calvet, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610620/
https://www.ncbi.nlm.nih.gov/pubmed/34556565
http://dx.doi.org/10.1212/WNL.0000000000012853