Perturbing the Normal Level of SIDT1 Suppresses the Naked ASO Effect

Although antisense oligonucleotide (ASO) therapeutics can be taken up by living cells without carrier molecules, a large part of incorporated ASOs are trapped in the endosomes and do not exert therapeutic effects. To improve their therapeutic effects, it would be important to elucidate the mechanism...

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Detalles Bibliográficos
Autores principales: Takahashi, Masayuki, Seki, Mineaki, Nashimoto, Masayuki, Kabuta, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610720/
https://www.ncbi.nlm.nih.gov/pubmed/34824869
http://dx.doi.org/10.1155/2021/2458470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610720/
https://www.ncbi.nlm.nih.gov/pubmed/34824869
http://dx.doi.org/10.1155/2021/2458470

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