HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells

HACE1, an E3 ubiquitin-protein ligase, is frequently inactivated and has been evidenced as a putative tumor suppressor in different types of cancer. However, its role in glioma remains elusive. Here, we observed increased expression of HACE1 in gliomas related to control subjects, and found a strong...

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Detalles Bibliográficos
Autores principales: Da, Chenxing, Pu, Jun, Liu, Zhe, Wei, Jing, Qu, Yiping, Wu, Yongxing, Shi, Bingyin, Yang, Jian, He, Nongyue, Hou, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611003/
https://www.ncbi.nlm.nih.gov/pubmed/34815381
http://dx.doi.org/10.1038/s41392-021-00793-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611003/
https://www.ncbi.nlm.nih.gov/pubmed/34815381
http://dx.doi.org/10.1038/s41392-021-00793-z

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