Deep Learning Enables Discovery of a Short Nuclear Targeting Peptide for Efficient Delivery of Antisense Oligomers

[Image: see text] Therapeutic macromolecules such as proteins and oligonucleotides can be highly efficacious but are often limited to extracellular targets due to the cell’s impermeable membrane. Cell-penetrating peptides (CPPs) are able to deliver such macromolecules into cells, but limited structu...

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Detalles Bibliográficos
Autores principales: López-Vidal, Eva M., Schissel, Carly K., Mohapatra, Somesh, Bellovoda, Kamela, Wu, Chia-Ling, Wood, Jenna A., Malmberg, Annika B., Loas, Andrei, Gómez-Bombarelli, Rafael, Pentelute, Bradley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611673/
https://www.ncbi.nlm.nih.gov/pubmed/34841414
http://dx.doi.org/10.1021/jacsau.1c00327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611673/
https://www.ncbi.nlm.nih.gov/pubmed/34841414
http://dx.doi.org/10.1021/jacsau.1c00327

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