Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro

Lewy bodies (LBs) are complex, intracellular inclusions that are common pathological features of many neurodegenerative diseases. They consist largely of aggregated forms of the protein alpha-Synuclein (α-Syn), which misfolds to give rise to beta-sheet rich amyloid fibrils. The aggregation of monome...

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Detalles Bibliográficos
Autores principales: Marotta, Nicholas P., Ara, Jahan, Uemura, Norihito, Lougee, Marshall G., Meymand, Emily S., Zhang, Bin, Petersson, E. James, Trojanowski, John Q., Lee, Virginia M.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611971/
https://www.ncbi.nlm.nih.gov/pubmed/34819159
http://dx.doi.org/10.1186/s40478-021-01288-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611971/
https://www.ncbi.nlm.nih.gov/pubmed/34819159
http://dx.doi.org/10.1186/s40478-021-01288-2

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