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Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro
Lewy bodies (LBs) are complex, intracellular inclusions that are common pathological features of many neurodegenerative diseases. They consist largely of aggregated forms of the protein alpha-Synuclein (α-Syn), which misfolds to give rise to beta-sheet rich amyloid fibrils. The aggregation of monome...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611971/ https://www.ncbi.nlm.nih.gov/pubmed/34819159 http://dx.doi.org/10.1186/s40478-021-01288-2 |